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Page 1
Did you mean inr and IRS2 (5 results)?
Single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 genes in the pathogenesis of polycystic ovary syndrome.
Thangavelu M, Godla UR, Paul Solomon FD, Maddaly R. Thangavelu M, et al. J Genet. 2017 Mar;96(1):87-96. doi: 10.1007/s12041-017-0749-z. J Genet. 2017. PMID: 28360393 Free article.
Here, we aimed to investigate the association of single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 gene in the pathogenesis of PCOS. ...The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the sou …
Here, we aimed to investigate the association of single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 ge …
Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population?
Karimi K, Mahmoudi T, Karimi N, Dolatmoradi H, Arkani M, Farahani H, Vahedi M, Parsimehr E, Dabiri R, Nobakht H, Asadi A, Zali MR. Karimi K, et al. Asian Pac J Cancer Prev. 2013;14(9):5011-6. doi: 10.7314/apjcp.2013.14.9.5011. Asian Pac J Cancer Prev. 2013. PMID: 24175768 Free article.
RESULTS: Overall, we observed no significant difference in genotype and allele frequencies between the cases and controls for the IGF-I, IGFBP-3, INSR, IRS2 gene variants and CRC before or after adjusting for confounders (age, BMI, sex, and smoking status). ...CONCL …
RESULTS: Overall, we observed no significant difference in genotype and allele frequencies between the cases and controls for the IGF-I, IGF …
Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.
Kim JJ, Kido Y, Scherer PE, White MF, Accili D. Kim JJ, et al. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1694-701. doi: 10.1152/ajpendo.00430.2006. Epub 2007 Feb 13. Am J Physiol Endocrinol Metab. 2007. PMID: 17299086 Free article.
To analyze how these two variables contribute to the progressive deterioration of metabolic control seen in diabetes, we asked whether mice with impaired beta-cell growth due to Irs2 ablation would be able to mount a compensatory response in the background of insulin resis …
To analyze how these two variables contribute to the progressive deterioration of metabolic control seen in diabetes, we asked whether mice …
Estradiol-dependent and independent effects of FGF21 in obese female mice.
Jakovleva TV, Kazantseva AY, Dubinina AD, Balybina NY, Baranov KO, Makarova EN, Bazhan NM. Jakovleva TV, et al. Vavilovskii Zhurnal Genet Selektsii. 2022 Mar;26(2):159-168. doi: 10.18699/VJGB-22-20. Vavilovskii Zhurnal Genet Selektsii. 2022. PMID: 35434487 Free PMC article.
This study is the f irst to show the modif ication of FGF21 effects by estradiol: inhibition of FGF21-inf luence on the expression of Irs2 and Pklr in the liver and potentiation of the FGF21-stimulated expression of Lepr and Klb in the hypothalamus. In addition, when admin …
This study is the f irst to show the modif ication of FGF21 effects by estradiol: inhibition of FGF21-inf luence on the expression of Irs …
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
Cardellini M, Menghini R, Luzi A, Davato F, Cardolini I, D'Alfonso R, Gentileschi P, Rizza S, Marini MA, Porzio O, Lauro D, Sbraccia P, Lauro R, Federici M. Cardellini M, et al. Diabetes. 2011 Dec;60(12):3265-70. doi: 10.2337/db11-0162. Epub 2011 Oct 7. Diabetes. 2011. PMID: 21984580 Free PMC article.
Here we have studied first-degree relatives of patients with type 2 diabetes to investigate whether a reduction in components of the insulin signal transduction pathways, such as the insulin receptor (InsR) or InsR substrate 1 or 2 (IRS1 or IRS2), or a reduct …
Here we have studied first-degree relatives of patients with type 2 diabetes to investigate whether a reduction in components of the insulin …
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance.
Cen HH, Hussein B, Botezelli JD, Wang S, Zhang JA, Noursadeghi N, Jessen N, Rodrigues B, Timmons JA, Johnson JD. Cen HH, et al. FASEB J. 2022 Jan;36(1):e22088. doi: 10.1096/fj.202100497RR. FASEB J. 2022. PMID: 34921686 Free PMC article.
Consistently, we observed that hyperinsulinemia led to a substantial reduction in Insr gene expression, and subsequently a reduced surface INSR and total INSR protein, both in vitro and in vivo. Bioinformatic modeling combined with RNAi identified SIN3A as a …
Consistently, we observed that hyperinsulinemia led to a substantial reduction in Insr gene expression, and subsequently a reduced su …
Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-κB molecular pathway.
Otoo A, Czika A, Lamptey J, Yang JP, Feng Q, Wang MJ, Wang YX, Ding YB. Otoo A, et al. Reproduction. 2023 Sep 28;166(5):323-336. doi: 10.1530/REP-22-0449. Print 2023 Nov 1. Reproduction. 2023. PMID: 37651270
Immunohistochemical staining of the ovaries revealed strong HMGB1, TLR4, and AR expressions in PCOS mice, which were lowered by emodin treatment. Moreover, emodin significantly increased GLUT4, IRS2, and INSR levels that were lowered by PCOS. Overall, our study show …
Immunohistochemical staining of the ovaries revealed strong HMGB1, TLR4, and AR expressions in PCOS mice, which were lowered by emodin treat …
Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and glutamine or glucose deprivation.
Minchenko DO, Kharkova AP, Hubenia OV, Minchenko OH. Minchenko DO, et al. Endocr Regul. 2013 Jan;47(1):15-26. doi: 10.4149/endo_2013_01_15. Endocr Regul. 2013. PMID: 23363253
METHODS: The expression of the INSR, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 genes in the glioma cell line U87 and its subline with ERN1 loss of function was studied by qPCR. ...Hypoxia affected the expression of the INSR, IRS1, IRS2, INSIG1, INSI …
METHODS: The expression of the INSR, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 genes in the glioma cell line U87 and its su …
Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta-analysis.
Shi X, Xie X, Jia Y, Li S. Shi X, et al. J Obstet Gynaecol Res. 2016 Jul;42(7):844-54. doi: 10.1111/jog.13002. Epub 2016 Apr 20. J Obstet Gynaecol Res. 2016. PMID: 27098445 Review.
AIM: Recently, the roles of insulin receptor (INSR) and insulin receptor substrate (IRS) polymorphisms in polycystic ovary syndrome (PCOS) have been extensively studied, with conflicting results. ...However, INSR His 1058 C/T polymorphism may not be implicated in PC …
AIM: Recently, the roles of insulin receptor (INSR) and insulin receptor substrate (IRS) polymorphisms in polycystic ovary syndrome ( …
Aerobic exercise improves cognitive impairment in mice with type 2 diabetes by regulating the MALAT1/miR-382-3p/BDNF signaling pathway in serum-exosomes.
Wang M, Xie K, Zhao S, Jia N, Zong Y, Gu W, Cai Y. Wang M, et al. Mol Med. 2023 Sep 22;29(1):130. doi: 10.1186/s10020-023-00727-1. Mol Med. 2023. PMID: 37740187 Free PMC article.
Silencing MALAT1 or overexpressing miR-382-3p could reduce the expression of INSR, IRS-1, IRS-2, PI3K/AKT, and Ras/MAPK, inhibit neuronal proliferation, and promote apoptosis. ...
Silencing MALAT1 or overexpressing miR-382-3p could reduce the expression of INSR, IRS-1, IRS-2, PI3K/AKT, and Ras/MAPK, inhibit neur …
92 results